Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter December 5, 2017

Emblica officinalis – Anti-obesity activity

  • Iram Nazish EMAIL logo and Shahid H Ansari

Abstract

Context

Emblica officinalis Gaertn. (family-Phyllanthaceae) fruits, known commonly as amla, is extensively used in Indian traditional system of medicine for the treatment of various disorders. The ethanolic E. officinalis extract is reported to have various activity such as antidiabetic, antihyperlipidemic and antioxidant activity in experimental animals.

Objective

To evaluate anti-obesity effect of aqueous E. officinalis extract in murine model of high fat diet (HFD)-induced obesity.

Materials and methods

Male Wistar rats fed with HFD (20 g/day/rat, p.o) for a period of 42 days were used to induce obesity. Aqueous E. officinalis extract (20 mg/kg bw) administered orally to HFD-fed rats from day 8 to 50 days for a period of 42 days. Body weight gain, serum lipids, insulin and leptin parameters were measured.

Results

Oral feeding of the aqueous E. officinalis extract (20 mg/kg) to HFD-induced obese rats for a period of 42 days resulted in significant reduction in body weight gain, insulin, leptin, lipids as compared to rats fed HFD alone. Further, the extract also showed significant increase in high density lipoprotein (HDL-C) levels.

Discussion and conclusions

These results show that aqueous E. officinalis extract possess significant anti-obesity potential.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

References

[1] Haslam DW, James WPT. Obesity. Lancet. 2005;366:1197–209.10.1016/S0140-6736(05)67483-1Search in Google Scholar PubMed

[2] Flegal KM, Graubard BI, Williamson DF, Gail MH. Cause-specific excess deaths associated with underweight, overweight, and obesity. JAMA. 2007;298:2028–37.10.1001/jama.298.17.2028Search in Google Scholar PubMed

[3] LeBlanc ES, O’Connor E, Wtitlock PD, Patnode CD, Kapka T. Effectiveness of primary care -relevant treatments for obesity in adults: a systematic evidence review for the U. S. Preventive Services Task Force. Ann Int Med. 2011;155:434–47.10.7326/0003-4819-155-7-201110040-00006Search in Google Scholar PubMed

[4] Chaput JP, St-Pierre S, Tremblay A. Currently available drugs for the treatment of obesity: sibutramine and orlistat. Mini Rev Med Chem. 2007;7:3–10.10.2174/138955707779317849Search in Google Scholar PubMed

[5] Karamadoukis L, Shivashankar GH, Ludeman L, Williams AJ. An unusual complication of treatment with orlistat. Clin Nephrol. 2009;71:430–32.10.5414/CNP71430Search in Google Scholar PubMed

[6] Mayer MA, Hocht C, Puyo A, Taira CA. Recent advances in obesity pharmacotherapy. Curr Clin Pharmacol. 2009;2009(4):53–61.10.2174/157488409787236128Search in Google Scholar PubMed

[7] Rayalam S, Della-Fera MA, Baile CA. Phytochemicals and regulation of the adipocyte life cycle. J Nutr Biochem. 2008;2008(19):717–26.10.1016/j.jnutbio.2007.12.007Search in Google Scholar PubMed

[8] Thielecke F, Boschmann M. The potential role of green tea catechins in the prevention of the metabolic syndrome – a review. Phytochemistry. 2009;70:11–24.10.1016/j.phytochem.2008.11.011Search in Google Scholar PubMed

[9] Jain SK, Khurdiya DS. Vitamin C enrichment of fruit juice based ready-to serve beverages through blending of Indian gooseberry (Emblica officinalis Gaertn.) juice. Plant Foods Hum Nutr. 2004;59(2):63–66.10.1007/s11130-004-0019-0Search in Google Scholar PubMed

[10] Suryanarayan P, Saraswat M, Petrash JM, Reddy GB. Emblica officinalis and its enriched tannoids delay streptozotocin-induced diabetic cataract in rats. Mol Vis. 2007;24(13):1291–97.Search in Google Scholar

[11] Dhanalakshmi S, Devi RS, Srikumar R, Muruganandam AV, Kumar V, Manikandan S, et al. Protective effect of Triphala on cold stress-induced behavioral and biochemical abnormalities in rats. Yakugaku Zasshi. 2007;127(11):1863–67.10.1248/yakushi.127.1863Search in Google Scholar PubMed

[12] Anonymous. Indian Pharmacopoeia. New Delhi, India: Government of India, 1996.Search in Google Scholar

[13] Trease GE, Evans WC. Pharmacognosy. Philadelphia: Bailliere Tindal Publisher and distributer, 1989.Search in Google Scholar

[14] Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499–502.10.1093/clinchem/18.6.499Search in Google Scholar PubMed

[15] Kaiyala KJ, Prigeon RL, Kahn SE, Woods SC, Porte DJ, Schwartz MW. Reduced beta-cell function contributes to impaired glucose tolerance in dogs made obese by high fat feeding. Am J Physiol Endocrinol Metab. 1999;277:659–66.10.1152/ajpendo.1999.277.4.E659Search in Google Scholar

[16] Kraegen EW, Clark PW, Jenkins AB, Daley EA, Chisholm DJ, Storlien LH. Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats. Diabetes. 1991;40:1397–403.10.2337/diab.40.11.1397Search in Google Scholar PubMed

[17] Mooradian AD, Chehade J, Hurd R, Haas MJ. Monosaccharide-enriched diets cause hyperleptinemia without hypophagia. Nutrition. 2000;16:439–41.10.1016/S0899-9007(00)00229-XSearch in Google Scholar PubMed

[18] Brown JL, Spicer MT, Spicer LJ. Effect of high-fat diet on body composition and hormone responses to glucose tolerance tests. Endocrine. 2002;19:327–32.10.1385/ENDO:19:3:327Search in Google Scholar PubMed

[19] K V A, Dikeakos A, Sclafani A. High Dietary Fat Promotes Syndrome X in Nonobese rats. J Nutr. 2003;133:2244–49.10.1093/jn/133.7.2244Search in Google Scholar PubMed

[20] O’Shaughnessy IM, Myeres TJ, Stepniakowski K, Nazzaro P, Kelly TM, Hoffmann RG, et al. Glucose metabolism in abdominally obese hypertensive and normotensive subjects. Hypertension. 1995;26:186–92.10.1161/01.HYP.26.1.186Search in Google Scholar PubMed

[21] Gabriely I, Ma XH, Atzmon G, Rajala MW, Berg AH, Scherer P, et al. Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process. Diabetes. 2001;51:2951–58.10.2337/diabetes.51.10.2951Search in Google Scholar

[22] Alam I, Lewis K, Stephenes JW, Baxter JN. Obesity, metabolic syndrome and sleep apnoea: all proinflammatory states. Obes Rev. 2006;8:119127.10.1111/j.1467-789X.2006.00269.xSearch in Google Scholar

[23] Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature. 1998;395:763–70.10.1038/27376Search in Google Scholar PubMed

[24] Uygun A, Kadayifci A, Yesilova Z, Erdil A, Yaman H, Saka M, et al. Serum leptin levels in patients with nonalcoholic steatohepatitis. Am J Gastroenterol. 2000;95:3584–89.10.1111/j.1572-0241.2000.03297.xSearch in Google Scholar PubMed

Received: 2016-5-31
Accepted: 2017-10-9
Published Online: 2017-12-5

© 2018 Walter de Gruyter GmbH, Berlin/Boston

Downloaded on 19.3.2024 from https://www.degruyter.com/document/doi/10.1515/jcim-2016-0051/html
Scroll to top button