Source Title:
Journal of Pediatric Endocrinology and Metabolism
|
Volume/Issue:
Volume 28: Issue 7-8

Rickets and vitamin D deficiency in Alaska native children

Rosalyn Singleton, Rachel Lescher 1 , Bradford D. Gessner 3 , Matthew Benson 1 , Lisa Bulkow 2 , John Rosenfeld 1 , Timothy Thomas 1 , Robert C. Holman 4 , Dana Haberling 4 , Michael Bruce 2 , Michael Bartholomew 5 , and James Tiesinga 1
  • 1 Alaska Native Tribal Health Consortium, Anchorage, AK, USA
  • 2 Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Centers for Disease Control and Prevention (CDC), Anchorage, AK, USA
  • 3 Epidemiology and Vaccinology Consulting, Anchorage, AK, USA
  • 4 Division of High-Consequence Pathogens and Pathology, NCEZID, CDC, Atlanta, GA, USA
  • 5 Indian Health Service, Rockville, MD, USA
Rosalyn Singleton, Rachel Lescher, Bradford D. Gessner, Matthew Benson, Lisa Bulkow, John Rosenfeld, Timothy Thomas, Robert C. Holman, Dana Haberling, Michael Bruce, Michael Bartholomew and James Tiesinga
DOI:
https://doi.org/10.1515/jpem-2014-0446
|
Published online:
04 Mar 2015

Abstract

Background: Rickets and vitamin D deficiency appeared to increase in Alaskan children starting in the 1990s. We evaluated the epidemiology of rickets and vitamin D deficiency in Alaska native (AN) children in 2001–2010.

Methods: We analyzed 2001–2010 visits with rickets or vitamin D deficiency diagnosis for AN and American Indian children and the general US population aged <10 years. We conducted a case-control study of AN rickets/vitamin D deficient cases and age- and region-matched controls.

Results: In AN children, annual rickets-associated hospitalization rate (2.23/100,000 children/year) was higher than the general US rate (1.23; 95% CI 1.08–1.39). Rickets incidence increased with latitude. Rickets/vitamin D deficiency cases were more likely to have malnutrition (OR 38.1; 95% CI 4.9–294), had similar breast-feeding prevalence, and were less likely to have received vitamin D supplementation (OR 0.23; 95% CI 0.1–0.87) than controls.

Conclusions: Our findings highlight the importance of latitude, malnutrition, and lack of vitamin D supplementation as risk factors for rickets.

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Article information

Corresponding author: Rosalyn Singleton, MD, MPH, Arctic Investigations Program, CDC, 4055 Tudor Centre Dr., Anchorage, AK 99508, USA, Phone: +1-907-729-3418, Fax: +1-907-729-3429, E-mail: ; and Alaska Native Tribal Health Consortium, Anchorage, AK, USA; and Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Centers for Disease Control and Prevention (CDC), Anchorage, AK, USA

Received:
2014-10-28
Accepted:
2015-01-29
Published Online:
2015-03-04
Published in Print:
2015-07-01

Citation Information: 
Journal of Pediatric Endocrinology and Metabolism, Volume 28, Issue 7-8, Pages 815–823, eISSN 2191-0251, ISSN 0334-018X, DOI: https://doi.org/10.1515/jpem-2014-0446.

©2015 by De Gruyter.

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Journal + Issues

Journal of Pediatric Endocrinology and Metabolism

Online ISSN:
2191-0251
First published:
01 Jan 1985
Language:
English
Publisher:
De Gruyter

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