Vitamin D status in perinatally HIV-infected Thai children receiving antiretroviral therapy

Linda Aurpibul 1 , Sirintip Sricharoenchai 2 , Orasri Wittawatmongkol 2 , Virat Sirisanthana 1 , Wanatpreeya Phongsamart 2 , Tavitiya Sudjaritruk 3 , and Kulkanya Chokephaibulkit 2
  • 1 Chiang Mai University
  • 2 Mahidol University
  • 3 Chiang Mai University
Linda Aurpibul, Sirintip Sricharoenchai, Orasri Wittawatmongkol, Virat Sirisanthana, Wanatpreeya Phongsamart, Tavitiya Sudjaritruk and Kulkanya Chokephaibulkit

Abstract

Background: Low vitamin D level is associated with adverse health outcomes and compromises HIV treatment response. We assess vitamin D status in HIV-infected Thai children receiving combination antiretroviral therapy (cART).

Methods: A cross-sectional study in perinatally HIV-infected children. Vitamin D deficiency and vitamin D insufficiency were defined as serum 25-hydroxyvitamin D (25-OHD) level <20, and 21–29 ng/mL, respectively.

Results: Eighty participants were enrolled. Their median age was 12.2 years. The median CD4 lymphocyte count was 784 cell/mm3; 95% had HIV RNA <50 copies/mL. The median (interquartile range, IQR) 25-OHD level was 33.5 (26.2–39.8) ng/mL. Thirty-four (43%) participants had low vitamin D level; 26 (33%) and 8 (10%) had vitamin D insufficiency and deficiency, respectively. In multivariate analysis, only geographic location was significantly associated with low vitamin D level.

Conclusions: Most of perinatally HIV-infected children receiving cART had low vitamin D level. Calcium and vitamin D supplement might be beneficial.

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