Increase of body mass index (BMI) from 1.5 to 3 years of age augments the degree of insulin resistance corresponding to BMI at 12 years of age

Osamu Arisaka 1 , Toshimi Sairenchi 2 , Go Ichikawa 3  and Satomi Koyama 3
  • 1 Department of Pediatrics, Dokkyo Medical University School of Medicine, Mibu, Tochigi-ken, 321-0293 Japan, Phone: +71-282-86-1111, Fax: +71-282-86-7521
  • 2 Department of Public Health, Dokkyo Medical University School of Medicine, Mibu, Japan
  • 3 Department of Pediatrics, Dokkyo Medical University School of Medicine, Mibu, Japan
Osamu Arisaka, Toshimi Sairenchi, Go Ichikawa and Satomi Koyama


To elucidate the effect of early growth patterns on the metabolic sensitivity to adiposity, we examined the relationship between the homeostatic model assessment of insulin resistance (HOMA-IR) and body mass index (BMI) levels at 12 years of age in 101 boys and 91 girls in a birth cohort. Children with an increase in BMI from the ages of 1.5 to 3 years exhibited a greater increase of HOMA-IR per BMI increase at 12 years of age compared to those with a decrease in BMI or stable BMI from 1.5 to 3 years. This suggests that children who show an increase in BMI from 1.5 to 3 years, a period normally characterized by a decreased or stable BMI, are more prone to developing insulin resistance at 12 years of age.

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The Journal of Pediatric Endocrinology and Metabolism (JPEM) is the only international journal dedicated exclusively to endocrinology in the neonatal, pediatric and adolescent age groups, and publishes the results of clinical investigations in pediatric endocrinology and basic research. JPEM publishes Review Articles, Original Research, Case Reports, Short Communications and Letters to the Editor.