Fatal outcome of pyoderma gangrenosum with multiple organ involvement and partially responding to Infliximab

Stefan Drinda 1 , Peter Oelzner 1 , Carolina Codina Canet 2 , Martin Kaatz 3 , Gunter Wolf 1 , and Gert Hein 1
  • 1 Department of Internal Medicine III, Friedrich Schiller University Jena, D 07740, Jena, Germany
  • 2 Department of Pathology, Friedrich Schiller University Jena, D 07740, Jena, Germany
  • 3 Department of Dermatology, Friedrich Schiller University Jena, D 07743, Jena, Germany

Abstract

Pyoderma gangrenosum is an inflammatory dermatosis of uncertain etiology, often associated with chronic inflammatory bowel or rheumatoid disease. It predominantly affects the skin. A systemic organ involvement caused by aseptic neutrophilic abscesses, however, fundamentally influences the prognosis.

A patient with idiopathic pyoderma gangrenosum insufficiently responded to a conventional immune suppressive therapy and the disease proceeded aggressively. During treatment with Infliximab, partial remission was achieved intermediately. However, a recurring endocarditis, led to a lethal outcome of this patient.

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