Detection and identification of atypical quetiapine metabolite in urine

Vasil Atanasov, Kamen Kanev 1 ,  and Mariana Mitewa 2
  • 1 Clinic of Emergency Toxicology and Allergology, Military Medical Academy, 3 G. Sofiiski Str, 1603, Sofia, Bulgaria
  • 2 Laboratory of Bioinorganic and Bioanalytical Chemistry, Department of Analytical Chemistry, Faculty of Chemistry, Sofia University, 1 J. Bourchier Ave., 1164, Sofia, Bulgaria

Abstract

Quetiapine fumarate (Seroquel®) is an atypical antipsychotic dibenzothiazepine derivative. Due to its extensive hepatic metabolism and low level of unchanged excretion (< 1%) the routine toxicological drug-screening analyses of urine often leads to false negative results. In the present study, we report that a newly identified metabolite of quetiapine, N-desalkylquetiapine, can be used as an indicative marker of quetiapine-intake in urine using common GC-MS screening procedure. The structure of the mentioned metabolite was solved from the mass-spectrum obtained and the quetiapine presence was proved by consequent HPLC plasma analysis.

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