Lung emphysema treated successfully using volume reduction with lung sealant (AeriSeal®)

Roger Fei 1 , Falkenstern-Ge 1 , Hermann Ingerl 1 , and Martin Kohlhäufl 1
  • 1 Division of Pulmonology, Klinik Schillerhoehe, Center for Pulmonology and Thoracic Surgery, Teaching Hospital of the University of Tuebingen, Solitude Str. 18, 70839, Stuttgart-Gerlingen, Germany


Emphysema is a progressive and irreversible disease for which there is no cure to date. Endoscopic lung volume reduction with valve implantation or using lung sealant is a treatment option for patients with severe emphysema. A 60-year-old ex-smoker (80 pack years) referred to our center because of severe lung emphysema with progressive worsening of the obstructive ventilator pattern and clinical condition. By our patient we detected collateral channels by using the Chartis system®, which allow airflow into the target lobe and prevent atelectasis and significant lung volume reduction. Thus, we decided to treat the advanced emphysema of our patient with endoscopic volume reduction using lung sealant (AeriSeal®). The foam of lung sealant AeriSeal® is instilled into the peripheral airways and alveoli where it polymerizes and functions as tissue glue, forming a film of material on the lung surface that seals the target region to cause durable absorption atelectasis. Over a period of 16 weeks, the air within the sealed region was absorbed. The follow- up evaluation of this patient showed improved lung function (increased FEV 1, and a reduction of TLC and RV) with improved quality of life. Correlation between changes in primary and secondary outcome measures in the lung function parameters and 6- minute-walking test before and after the application of AeriSealant revealed significant reduction of hyperinflation and improvement both in the flow rates and physical capacity of our patient.

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • [1] Herth FJ, Gompelmann D, Stanzel F et. al Treatment of advanced emphysema with emphysematous lung sealant (AeriSeal®). Respiration. 2011;82(1):36–45. Epub 2011 Jan 11

  • [2] Criner GJ, Sternberg AL. National Emphysema Treatment Trial: the major outcomes of lung volume reduction surgery in severe emphysema. Proc Am Thorac Soc. 2008 May 1;5(4):393–405

  • [3] Shah PL, Slebos DJ, Cardoso PF, et al. Bronchoscopic lung- volume reduction with Exhale airway stents for emphysema (EASE trial): randomised, sham- controlled, multicentre trial. Lancet 2011; 378: 997–1005

  • [4] Sciurba FC, Ernst A, Herth FJ, et al. A randomized study of endobronchial valves for advanced emphysema. N Eng J Med 2010; 363: 1233–1244

  • [5] Maxfield RA. New and emerging minimally invasive techniques for lung volume reduction. Chest 2004;125:777–783

  • [6] Ingenito EP, Berger RL, Henderson AC, Reilly JJ, Tsai L, Hoffman A. Bronchoscopic lung volume reduction using tissue engineering principles. Am J Respir Crit Care Med 2003;167:771–778

  • [7] Ingenito EP, Douglas E. Wood, and James P. Utz Bronchoscopic Lung Volume Reduction in Severe Emphysema Proc Am Thorac Soc 2008 May 1;5(4):454–460

  • [8] Herth FJ, Eberhardt R, Ingenito EP and Gompelmann D. Assessment of a novel lung sealant for performing endoscopic volume reduction therapy in patients with advanced emphysema. Expert Rev Med Devices 2011 8(3), 307–312


Journal + Issues