The latent cytomegalovirus decreases telomere length by microcompetition

Hanan Polansky 1  and Adrian Javaherian 1
  • 1 The Center for the Biology of Chronic Disease (CBCD), Valley Cottage, NY 10989, USA

Abstract

Reduced telomere length has been associated with aging and age-related diseases. Latent infection with the Cytomegalovirus (CMV) induces telomere shortening in the infected cells. Latent CMV infection may cause reduced telomere length via GABP transcription factor deficiency, according to the Microcompetition Theory. Microcompetition and viral-induced transcription factor deficiency is important since most people harbor a latent viral infection.

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  • [1] Drury S.S., Theall K., Gleason M.M., Smyke A.T., De Vivo I., Wong J.Y.Y. et al., Telomere length and early severe social deprivation: linking early adversity and cellular aging, Mol. Psychiatry, 2012, 17(7), 719-727

  • [2] van de Berg P.J., Griffiths S.J., Yong S.L., Macaulay R., Bemelman F.J., Jackson S. et al., Cytomegalovirus Infection Reduces Telomere Length of the Circulating T Cell Pool, J. Immunol. 2010, 184, 3417-3423

  • [3] Polansky H., Microcompetition with Foreign DNA and the Origin of Chronic Disease., The Center for the Biology of Chronic Disease, New York, 2003

  • [4] Liu B.H., Wang X., Ma Y.X., Wang S., CMV Enhancer/Human PDGF-Beta Promoter for Neuron-Specific Transgene Expression, Gene Ther., 2004, 11(1), 52-60

  • [5] Slobedman B., Mocarski E.S., Quantitative Analysis of Latent Human Cytomegalovirus, J. Virol., 1999, 73(6), 4806-4812

  • [6] Adam G.I., Miller S.J., Ulleras E., Franklin G.C., Cell-Type- Specific Modulation of PDGF-B Regulatory Elements via Viral Enhancer Competition: A Caveat for the Use of Reference Plasmids in Transient Transfection Assays, Gene, 1996, 178(1), 25-29

  • [7] Yu S., Cui K., Jothi R., Zhao D.M., Jing X., Zhao K. et al., GABP controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells, Blood, 2011, 117(7), 2166-2178

  • [8] Sarek G., Vannier J.B., Panier S., Petrini J.H.J., Boulton S.J., TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding, Molecular Cell, 2015, 57(4), 622-635

  • [9] Spyridopoulos I., Hoffmann J., Aicher A., Brummendorf T.H., Doerr H.W., Zeiher A.M. et al., Accelerated Telomere Shortening in Leukocyte Subpopulations of Patients With Coronary Heart Disease, Circulation, 2009, 120, 1364-1372

  • [10] Nan W.Q., Ling Z., Bing C., The influence of the telomeretelomerase system on diabetes mellitus and its vascular complications, Expert Opin. Ther. Targets., 2015, 19(6)

  • [11] Ji Y.N., An L., Zhan P., Chen X.H., Cytomegalovirus infection and coronary heart disease risk: a meta-analysis, Molecular Biology Reports, 2012, 39(6), 6537-6546

  • [12] Mendy A., Gasana J., Vieira E.R., Diallo H., Prospective study of cytomegalovirus seropositivity and risk of mortality from diabetes, Acta Diabetol., 2014, 51, 723-729

  • [13] Green M., Michaels M.G., Epstein-Barr Virus Infection and Posttransplant Lymphoproliferative Disorder, Am. J. Transplant., 2013, 13(s3), 41-54

  • [14] Reddehase M.J., Cytomegaloviruses: From Molecular Pathogenesis to Intervention. Volume 2, Horizon Scientific Press, United Kingdom, 2013

  • [15] Bernstein D.I., Bellamy A.R., Hook III E.W., Levin M.J., Wald A., Ewell M.G. et al., Epidemiology, Clinical Presentation, and Antibody Response to Primary Infection With Herpes Simplex Virus Type 1 and Type 2 in Young Women, Clin. Infect. Dis., 2013, 56(3), 344-351

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