The latent cytomegalovirus decreases telomere length by microcompetition

Hanan Polansky 1  and Adrian Javaherian 1
  • 1 The Center for the Biology of Chronic Disease (CBCD), Valley Cottage, NY 10989, USA


Reduced telomere length has been associated with aging and age-related diseases. Latent infection with the Cytomegalovirus (CMV) induces telomere shortening in the infected cells. Latent CMV infection may cause reduced telomere length via GABP transcription factor deficiency, according to the Microcompetition Theory. Microcompetition and viral-induced transcription factor deficiency is important since most people harbor a latent viral infection.

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