Synthetic studies toward the spiroimine unit of the spirolides

Synthetic studies toward the spiroimine unit of the spirolide family of shellfish biotoxins are described. Several strategies for introduction of the C7, C29, and C32 stereocenters of the A,E-ring system of the spirolides are described, such as spironitrone formation, Birch reductive alkylation, and asymmetric Diels–Alder cycloadditions.

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Pure and Applied Chemistry is the official monthly Journal of the International Union of Pure and Applied Chemistry (IUPAC), with responsibility for publishing works arising from those international scientific events and projects that are sponsored and undertaken by the Union.

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