Molecular imaging of the serotonin 5-HT7 receptors: from autoradiography to positron emission tomography

Luc Zimmer and Thierry Billard 3
  • 1 University of Lyon 1, CNRS, INSERM, Lyon Neuroscience Research Center (CRNL), Lyon, France
  • 2 Hospices Civils de Lyon, 59 Boulevard Pinel, 69003 Lyon, France
  • 3 University of Lyon 1, CNRS, Institute of Chemistry and Biochemistry (ICBMS), Lyon, France
Luc Zimmer
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  • Luc Zimmer received a pharmacist education at the University of Strasbourg (1986–1992); he completed training during his internship and residency in radiopharmacy and radiopharmacology (1993–1999) at the Hospital University of Tours (Nuclear Medicine Department) and at the National Institute for Nuclear Sciences and Technology, Saclay. He received his PharmD in radiopharmacology (1998) and his PhD in neuroscience (1999) from the University of Tours. He is currently professor of pharmacology at the University of Lyon (Université Claude Bernard Lyon 1) and is radiopharmacist at the University Hospital of Lyon (Hospices Civils de Lyon). He is head of the preclinical department of the CERMEP-imaging platform and is in charge of the laboratory ‘Radiopharmaceutical and neurochemical biomarkers’ at the Lyon Neuroscience Research Center (CRNL). His research interests include radiopharmacology and in vivo imaging of neurotransmissions with PET.
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and Thierry Billard
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  • Thierry Billard, after education in chemistry, completed by an engineer diploma from ‘Institut de Chimie et Physique Industrielles de Lyon’ (now ‘CPE Lyon’) in 1993. He obtained his PhD in organic chemistry from the University of Lyon in 1996. After a post-doctoral internship with Prof. L. Ghosez (Université Catholique de Louvain, Belgium), he was appointed in 1999 as a CNRS permanent researcher. He was promoted Research Director by CNRS in 2008. He is currently in charge of a research team at the Institute of Chemistry and Biochemistry (ICBMS). His research activities focus on fluorine chemistry, medicinal chemistry, radiochemistry and their applications in medical imaging.
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Abstract

Serotonin and its various receptors are involved in numerous brain functions and neuropsychiatric disorders. Of the 14 known serotoninergic receptors, the 5-HT7 receptor is the most recently identified and characterized. It is closely involved in the pathogenesis of depression, anxiety, epilepsy and pain and is therefore an important target for drug therapy. It is a crucial target in neuroscience, and there is a clear need for radioligands for in vitro and in vivo visualization and quantification, first in animal models and ultimately in humans. This review focuses on the main radioligands suggested for in vitro and in vivo imaging of the 5-HT7 receptor.

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Reviews in the Neurosciences provides a forum for reviews, critical evaluations and theoretical treatment of selective topics in the neurosciences. The journal provides an authoritative reference work for those interested in the structure and functions of the nervous system at all levels of analysis, including the genetic, molecular, cellular, behavioral, cognitive and clinical neurosciences.

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