Development of bioimpedance sensing device for wearable monitoring of the aortic blood pressure curve

  • 1 Tallinn University of Technology, Tallinn, Estonia
H. Kõiv
  • 54561Tallinn University of Technology, Thomas Johann Seebeck Department of Electronics, Tallinn, Estonia
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  • Hip Kõiv was born in Kanepi, Estonia in 1990. She received the B. S. degree in electronics and bionics in 2013 and the M. S. degree in electronics and communication in 2015 from Tallinn University of Technology. She is currently pursuing the Ph. D. degree in Thomas Johann Seebeck Department of Electronics at Tallinn University of Technology and her current research interests include the bioimpedance study, aortic blood pressure measurements and the materials for developing biological phantoms.
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, M. Rist
  • 54561Tallinn University of Technology, Thomas Johann Seebeck Department of Electronics, Tallinn, Estonia
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  • Marek Rist was born in Tallinn, Estonia, in 1980. He received the M. Sc. degree in electronics and biomedical engineering in 2007, in Tallinn University of Technology, Tallinn, Estonia with a thesis on technology for measurement of impedance of lithium-ion batteries. He is currently pursuing the Ph. D. degree in electronics engineering in Tallinn University of Technology where he is involved in several projects related to electrical impedance spectroscopy.
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and M. Min
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  • 54561Tallinn University of Technology, Thomas Johann Seebeck Department of Electronics, Tallinn, Estonia
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  • Mart Min (M’95–SM’13) received the Diploma Engineer’s qualification in electronics from Tallinn University of Technology (TUT), Estonia, in 1969 and the Ph. D. degree in measurement science from Kiev Polytechnic, Ukraine, in 1984. He has been with Thomas Johann Seebeck Department of Electronics of the TUT as a Professor and a Leading Scientist since 1992. During 1992–1993, he was with the Technical University of Munich and the Bundeswehr University in Munich, Germany, as a Guest Scientist and a Professor. During 2007–2010, he joined the Institute of Bioprocessing and Analytical Measurement Technique in Heilbad Heiligenstadt, Germany. He is interested in measurement and processing of bio-signals with implementations in industry, including developing of pacemakers for the companies St. Jude Medical (USA/Sweden) and Guidant/Cardiac Pacemakers (USA). He is a member of Instrumentation & Measurement and Engineering in Biology and Medicine Societies of the IEEE. Prof. Min belongs to the International Committee for Promotion of Research in Bio-Impedance (ICPRBI).
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Abstract

Wearable devices that monitor our vital signs have been gaining more importance with each year. Non-invasive, continuous, accurate and precise blood pressure assessment method integrated in a wearable is a multidisciplinary challenge. This work presents an electrical bioimpedance (EBI) unit for multi-frequency measurements on pulsating artery for central aortic pressure (CAP) estimation. The developed device provides low complexity in the electronics design with a frequency range between 1 kHz and 200 kHz. It is able to register the impedance of blood vessel volume change simultaneously at different locations. Experiments were carried out in vivo by using the four-electrode configuration on human thorax, axillary artery and radial artery. Preliminary results show the applicability of the proposed impedance spectroscopy system to measure blood vessel volume changes. The impedance data can be later interpreted into the aortic blood pressure wave by using a generalized transfer function. In addition, experimental test-phantom and electrode design are introduced for testing purposes of the impedance system.

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