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BY-NC-ND 3.0 license Open Access Published by De Gruyter June 2, 2014

Beiträge zur Synthese von Cystinpeptiden, dargestellt am Beispiel der Totalsynthese von Humaninsulin* / Contributions to the Synthesis of Cystine Peptides Illustrated by the Total Synthesis of Human Insulin

  • Bruno Kamber

Abstract

The formation of disulfide bonds in separate chemical steps in a cystine peptide containing several cystine residues is exemplified by the synthesis of human insulin. The synthetic methods which made this approach feasible were 1) the thiol-induced fragmentation of sulfenyl thiocarbonate derivatives and 2) the conversion of S-trityl- and S-acetamidomethyl cysteine peptides to cystine peptides by oxidation with iodine.

Received: 1981-1-26
Published Online: 2014-6-2
Published in Print: 1981-4-1

© 1946 – 2014: Verlag der Zeitschrift für Naturforschung

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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