Hexafluoraceton als Schutzgruppen- und Aktivierungsreagenz in der Aminosäure- und Peptidchemie N-Substituierte Glycinderivate aus Iminodiessigsäure/Application of Hexafluoroacetone as Protecting and Activating Reagent in Amino Acid and Peptide Chemistry N -Substituted Glycine Derivatives from Iminodiacetic Acid

Klaus Burger 1 , Horst Neuhauser 1  and Anteneh Worku 1
  • 1 Institut für Organische Chemie der Technischen Universität München, Lichtenbergstraße 4, D-W-8046 Garching bei München

3-Carboxymethyl-2,2-bis(trifluoromethyl)-oxazolidin-5-one 2, obtained on reaction of iminodiacetic acid 1 and hexafluoroacetone, represents a preparatively useful intermediate for the synthesis of unsymmetrically substituted derivatives of the dicarboxylic acid 1. The N-substituted glycine derivatives obtained are interesting candidates for peptide modification.

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Zeitschrift für Naturforschung B is an international scientific journal which publishes original papers, microreviews, and letters from all areas of inorganic chemistry, solid state chemistry, coordination chemistry, molecular chemistry, and organic chemistry.