Zugänge zu Isomeren und Verwandten der Lamellarin-Alkaloide / Approach to Isomers and Structural Relatives of the Lamellarin Alkaloids

Johannes Tauber 1 , Dennis Imbri 2 , Vanessa C. Colligs 2 , and Prof. Dr. Till Opatz 3
  • 1 Universität Mainz, Institut für Organische Chemie, Duesbergweg 10 – 14, 55128 Mainz, Deutschland
  • 2 Johannes Guttenberg-Universität Mainz, Institut für Organische Chemie, Duesbergweg 10 – 14, 55128 Mainz, Deutschland
  • 3 Johannes Gutenberg-Universität Mainz, Institut für Organische Chemie, Duesbergweg 10 – 14, 55128 Mainz, Deutschland

Synthetic approaches to novel isomers and unprecedented structural relatives of the lamellarin alkaloids are reported. During our studies on methods to construct the lamellarin skeleton, we found the condensation of chroman-4-one derivatives with 1-benzyl-3,4-dihydroisoquinolines or the Pdcatalyzed cyclocarbonylation of o-halogenated precursors followed by Baeyer-Villiger oxidation to be unsuitable. Nevertheless, these routes produced interesting structural relatives of the natural alkaloids.

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    Zugänge zu Isomeren und Verwandten der Lamellarin-Alkaloide / Approach to Isomers and Structural Relatives of the Lamellarin Alkaloids