Receptor Specificity and Threshold Concentration in Chemotaxis of the Phaeophyte Cutleria multifida

Wilhelm Boland 1 , Karin Jakoby 1 , Lothar Jaenicke 1 , Dieter G. Müller 2  and Eisbet Fölster 2
  • 1 Institut für Biochemie der Universität zu Köln, An der Bottmühle 2, D-5000 Köln 1, Bundesrepublik Deutschland
  • 2 Universität Konstanz, Fachbereich Biologie, D-7750 Konstanz, Bundesrepublik Deutschland

Sexual reproduction has a decisive function during the life cycle of all organisms. In the marine brown alga Cutleria multifida, multifidene (1), a low molecular weight olefinic hydrocarbon, has been recognized as a chemical messenger for gamete union. Comparative activity tests with 32 specially designed synthetic analogous of the natural attractant demonstrate the high specifity and low threshold concentration (6.5 × 10-12 mol/L) of the gamete’s receptor system toward its natural signal (1). The findings establish the double bonds of multifidene (1) as the molecular coordination points in the messenger-receptor interaction. A tentative model is presented, which takes into account the evidence, that unpolar, but highly polarizable functional groups in the correct spatial arrangement are necessary for maximal mutual interaction

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A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) is an international scientific journal for the emerging field of natural and natural-like products. ZNC publishes original research on the isolation, bio-chemical synthesis and bioactivities of natural products, their biochemistry, pharmacology, biotechnology, and biological activity and innovative developed computational methods for predicting their structure and/or function.