Effect of Glucocorticoids, Insulin and a Growth Promoting Tripeptide on the Biosynthesis of Plasma Proteins in Serum-Free Hepatocyte Cultures

Fouad M. Fouad 1 , Mohamed Abd-El-Fattah 1 , Reiner Scherer 1 ,  and Gerhard Ruhenstroth-Bauer 1
  • 1 Max-Planck-Institut für Biochemie, D-8033 M artinsried bei München, Bundesrepublik Deutschland

The effect of cortisol, dexamethasone, insulin and a liver cell growth promoting tripeptide on the secretion of plasma proteins into the medium of rat hepatocytes in monolayer cultures was studied. Cortisol and dexamethasone resulted in ~ 2.5-fold increase in the fibrinogen synthesis with general supression of album in and α-lipoprotein synthesis. On the other hand, insulin inhibited the biosynthesis of most plasma proteins except for the complement system and transferrin. Concentrations of α-lipoprotein, a-1-macroglobulin and haptoglobin were moderately elevated when the tripeptide Gly-His-Lys was applied in low concentration

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A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) is an international scientific journal for the emerging field of natural and natural-like products. ZNC publishes original research on the isolation, bio-chemical synthesis and bioactivities of natural products, their biochemistry, pharmacology, biotechnology, and biological activity and innovative developed computational methods for predicting their structure and/or function.