Serological and Structural Comparison of Immunodeficiency Viruses from Man, African Green Monkey, Rhesus Monkey and Sooty Mangabey

E. Jurkiewicz 1 , G. Hunsmann 1 , M. Hayami 2 , Y. Ohta 2 ,  and H. Schmitz 3
  • 1 Deutsches Primaten-Zentrum, D-3400 Göttingen. Bundesrepublik Deutschland
  • 2 The Institute of Medical Science, University of Tokyo, Japan
  • 3 Bernhard-Nocht-Institut, D-2000 Hamburg. Bundesrepublik Deutschland

We have studied the serological relationship among the human immunodeficiency virus type 1 (HIV-1), and three simian immunodeficiency viruses (SIV). SIVagm was isolated from African green monkeys (Cercopithecus aethiops), and compared with the previously described isolates of SIVmac from a rhesus macaque (Macaca mulatta) and SIVsm from a sooty mangabey (Cercocebus atys). With respect to the glycoproteins, the simian viruses represent a subgroup apparently different from HIV . To classify HIV and SIV isolates further, we compared tryptic peptide maps of the core polypeptides p18 and p24 of HIV-2, three HIV-1 and five SIV isolates. Each peptide map was distinguishable, and differences are most prominent between the HIV-1 group and the SIVmac/SIVsm group. HIV-2 is very similar to SIVmac and SIVsm. The three SIVagm isolates form a more heterogeneous group. The p24s of all SIVagms are more similar to the p24s of HIV-1, but with respect to p18, one isolate is similar to HIV-1, while the two others are more related to SIVmac, SIVsm, and HIV-2.

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A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) is an international scientific journal for the emerging field of natural and natural-like products. ZNC publishes original research on the isolation, bio-chemical synthesis and bioactivities of natural products, their biochemistry, pharmacology, biotechnology, and biological activity and innovative developed computational methods for predicting their structure and/or function.