Coprinol, a New Antibiotic Cuparane from a Coprinus Species

Martin Johansson 1 , Olov Sterner 2 , Harald Labischinski 3 ,  and Timm Anke 4
  • 1 Division of Organic Chemistry 2, Chemical Center, University of Lund, P.O.B ox 124, S-221 00 Lund, Sweden
  • 2 Division of Organic Chemistry 2, Chem ical Center, University of Lund, P.O.Box 124, S-221 00 Lund, Sweden
  • 3 Bayer AG, PH-Research Antibacterial Therapy I, D -42096 Wuppertal, Germany
  • 4 Institut für Biotechnologie und Wirkstoff-Forschung IBWF e. V., Erwin-Schrödinger-Str. 56, D-67663 Kaiserslautern, Germany

Abstract

Coprinol, a new antibacterial cuparane, was isolated from fermentations of a Coprinus sp. Its biological activities were investigated and its structure was elucidated by spectroscopic methods. The new antibiotic exhibited activitiy against multidrug-resistant Gram -positive bacteria in vitro. Two derivatives were synthesized and their activities compared to the parent compound.

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A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) is an international scientific journal for the emerging field of natural and natural-like products. ZNC publishes original research on the isolation, bio-chemical synthesis and bioactivities of natural products, their biochemistry, pharmacology, biotechnology, and biological activity and innovative developed computational methods for predicting their structure and/or function.

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