Pyrrolizidine Alkaloids from Lithospermum canescens Lehm.

Helmut Wiedenfeld 1 , Agnieszka Pietrosiuk 2 , Miroslava Furmanowa 2  and Erhard Roeder 1
  • 1 Pharmazeutisches Institut der Universität, An der Immenburg 4, D-53121 Bonn. F. R. G.
  • 2 Department of Biology and Pharmaceutical Botany, Medical University of Warsaw, Banacha Str. 1, 02-097 Warsaw, Poland

Seven pyrrolizidine alkaloids (PAs) have been isolated from Lithospermum canescens and their structures determined by spectroscopical methods. Besides the known lycopsamine, O7- acetyl-lycopsamine and O7-acetylintermedine four new PAs were found. Their structures are O7-(3-hydroxy-3-methyl-butanoyl)-O9-(+)-trachelanthoyl-heliotridine (= O7-(3-hydroxy-3- methyl-butanoyl)-rinderine = canescine), O7-(3-hydroxy-3-methyl-butanoyl)-O9-(D)-viridifloryl- heliotridine (= O7-(3-hydroxy-3-methyl-butanoyl)-echinatine = canescenine) and their O13-acetyl-derivatives (= acetylcanescine; acetylcanescenine).

If the inline PDF is not rendering correctly, you can download the PDF file here.


Journal + Issues

A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) is an international scientific journal for the emerging field of natural and natural-like products. ZNC publishes original research on the isolation, bio-chemical synthesis and bioactivities of natural products, their biochemistry, pharmacology, biotechnology, and biological activity and innovative developed computational methods for predicting their structure and/or function.