Pharmacological and Phytochemical Evaluation of Adiantum cuneatum Growing in Brazil

Louisiane F. V. Bresciani 1 , Jacks P. Priebe 2 , Rosendo Augusto Yunes 1 , Jacir Dal Magro 3 , Franco Delle Monache 4 , Fátima de Campos 5 , Márcia Maria de Souza 5  and Valdir Cechinel-Filho 5
  • 1 Departamento de Química, Universidade Federal de Santa Catarina (UFSC), Florianópolis-SC, Brasil
  • 2 Departamento de Quıímica, Universidade Federal de Santa Catarina (UFSC), Florianópolis-SC, Brasil
  • 3 Centro de Ciências Agro-Ambientais e de Alimentos, Universidade do Oeste do Estado de Santa Catarina (UNOESC), Chapecó-SC, Brasil
  • 4 Centro Chimica Recettori, CNR, Rome, Italy
  • 5 Núcleo de Investigações Químico-Farmacêuticas (NIQFAR)/CCS, Universidade do Vale do Itajaí (UNIVALI), Itajaí-SC, Brasil

This work describes the phytochemical analysis and analgesic activity of a non polar fraction obtained from Adiantum cuneatum grown in Brazil. The results showed that the hexane fraction as well as two pure compounds, identified as filicene (1) and filicenal (2), given intraperitoneally, exhibited potent analgesic activity when evaluated in two models of pain in mice, writhing test and formalin-induced pain. Compound 1 presented a calculated ID50 value of 19.5 μmol/kg body weight, when evaluated in writhing test, being about 7-fold more active than some reference drugs, like as acetyl salicylic acid and acetaminophen. It also inhibited both phases (neurogenic and inflammatory) of the formalin test at 10 mg/kg (24 μmol/kg). The chemical composition of the plant grown in Brazil is similar to that grown in other countries. The results confirm and justify the popular use of this plant for the treatment of dolorous processes.

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A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) is an international scientific journal for the emerging field of natural and natural-like products. ZNC publishes original research on the isolation, bio-chemical synthesis and bioactivities of natural products, their biochemistry, pharmacology, biotechnology, and biological activity and innovative developed computational methods for predicting their structure and/or function.