Antimicrobial Activity and Main Chemical Composition of Two Smoke Condensates from Peganum harmala Seeds

Ahmad R. Shahverdi 1 , Hamid R. Monsef-Esfahani 2 , Bahman Nickavar 3 , Lila Bitarafan 2 , Samira Khodaee 1 , and Narges Khoshakhlagh 2
  • 1 Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, 14174 Tehran, Iran
  • 2 Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  • 3 Department of Pharmacognosy, Faculty of Pharmacy, University of Shahidbeheshti, Tehran, Iran

Abstract

The smoke of Peganum harmala seeds is traditionally used in Iran as a disinfectant agent. The aim of this study was to determine the antimicrobial activity of two smoke condensates from Peganum harmala seeds. Furthermore the composition of smoke preparations was studied using gas chromatography and mass spectroscopy analysis. The most prevalent compound detected in a dichloromethane extract was harmine. Standard harmine as well as the dichloromethane extract showed antimicrobial activity against all test strains. Harmine was not detected in an n-hexane extract and we did not observe antimicrobial activity from this smoke preparation at the tested concentrations.

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