Antifungal Activity of Coumarins

Cristina Montagner 1 , Simone M. de Souza 1 , Cláudia Groposo 1 , Franco Delle Monache 2 , Elza F. A. Smânia 1  and Artur Smânia Jr 1
  • 1 Departamento de Microbiologia e Parasitologia, Centro de Ciências Biológicas da Universidade Federal de Santa Catarina, Campus Universitário, Trindade, Florianópolis-SC 88040-900, Brazil
  • 2 Centro Chimica dei Recettori (CNR), Universitá Cattolica del Sacro Cuore, Largo Francesco Vito, 1, Roma 00168, Italy

The antifungal activity of 40 coumarins was tested against the fungal strains: Candida albicans (ATCC 14053), Aspergillus fumigatus (ATCC 16913) and Fusarium solani (ATCC 36031), using the broth microdilution method. Osthenol showed the most effective antifungal activity among all the compounds tested, with a MIC value of 125 μg/ml for Fusarium solani and 250 μg/ml for Candida albicans and Aspergillus fumigatus. The antifungal potential of this prenylated coumarin can be related to the presence of an alkyl group at C-8 position.

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A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) is an international scientific journal for the emerging field of natural and natural-like products. ZNC publishes original research on the isolation, bio-chemical synthesis and bioactivities of natural products, their biochemistry, pharmacology, biotechnology, and biological activity and innovative developed computational methods for predicting their structure and/or function.