Evaluation of Lavandula stoechas L. subsp. stoechas L., Mentha spicata L. subsp. spicata L. essential oils and their main components against sinusitis pathogens

Nursenem Karaca 1 , Betül Demirci 2 ,  and Fatih Demirci 3
  • 1 Department of Pharmacognosy, Graduate School of Health Sciences, Anadolu University, Eskişehir, Turkey
  • 2 Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey
  • 3 Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, 26470-Eskişehir, Turkey
Nursenem Karaca
  • Department of Pharmacognosy, Graduate School of Health Sciences, Anadolu University, Eskişehir, Turkey
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, Betül Demirci
  • Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey
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and Fatih Demirci
  • Corresponding author
  • Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, 26470-Eskişehir, Turkey, demircif@gmail.com
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Abstract

Lavandula stoechas subsp. stoechas and Mentha spicata subsp. spicata are used for the treatment of sinusitis in Turkish folk medicine. The components of essential oils obtained by hydrodistillation were determined by gas chromatography-flame ionization detector (GC-FID), gas chromatography/mass spectrometry (GC/MS), and thin layer chromatography (TLC). Major components of L. stoechas and M. spicata oils were determined as camphor (46.7%) and carvone (60.6%), respectively. The antibacterial activity of essential oils and their main components were tested against the common selected sinusitis pathogens Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus aureus, Haemophilus influenzae, Moraxella catarrhalis, and Pseudomonas aeruginosa using in vitro agar diffusion, microdilution, and vapor diffusion methods. As a result, the tested plant materials, which are locally and natively used against sinusitis, were relatively mild antibacterial (in vitro MICs 310–1250 μg/mL) in action. To use essential oils and their components safely in sinusitis therapy, further detailed in vivo experiments are needed to support their efficacy.

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A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) is an international scientific journal for the emerging field of natural and natural-like products. ZNC publishes original research on the isolation, bio-chemical synthesis and bioactivities of natural products, their biochemistry, pharmacology, biotechnology, and biological activity and innovative developed computational methods for predicting their structure and/or function.

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