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Volume 2

Biochemistry, Biosynthesis and Human Diseases

Ed. by Rouault, Tracey

With contrib. by Maio, Nunziata / Dos Santos, Patricia / Dean, Dennis / Outten, Wayne / Outten, Caryn / Mettert, Erin L. / Kiley, Patricia / Dancis, Andy / Tong, Wing Hang / Leimkühler, Silke / Gari, Kerstin / Lill, Roland / Wohlschlegel, James / Peters, John / Boyd, Eric S. / Shepard, Eric M. / Broderick, Joan B. / Adams, Michael W.W. / Ye, Hong

    99,95 € / $140.00 / £91.00*

    eBook (EPUB)
    2nd Edition
    Publication Date:
    September 2017
    See all formats and pricing


  • Mechanisms of FeS cluster interaction with oxygen.
  • Overview of FeS protein synthesis in model organisms.
  • Relationship of FeS proteins role in human diseases and drug discovery.
  • Aims and Scope

    This volume on iron-sulfur proteins includes chapters that discuss how microbes, plants, and animals synthesize these complex prosthetic groups, and why it is important to understand the chemistry and biogenesis of iron sulfur proteins. In addition to their vital importance in mitochondrial respiration, numerous iron sulfur proteins are important in maintenance of DNA integrity. Multiple rare human diseases with different clinical presentations are caused by mutations of genes in the iron sulfur cluster biogenesis pathway. Understanding iron sulfur proteins is important for understanding a rapidly expanding group of metabolic pathways important in all kingdoms of life, and for understanding processes ranging from nitrogen fixation to human disease.


    xxi, 470 pages
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    Tracey Rouault, NIH Bethesda, Maryland, USA


    "[...] I have enjoyed reading this volume enormously. I believe that it is well balanced and there is very little redundancy between the different chapters, which nicely complement one another. In this respect one should congratulate the overall editor Tracey Rouault. I think it is a great contribution to the field of iron–sulfur proteins and a great tool for students to understand the broad significance of these reactions in biology. I strongly recommend that all groups interested in this field purchase it together with the first volume, it is a very good investment."
    Jean-Pierre Jacquot in: Acta Cryst. (2018). D74, 381–382

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