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Mertens, Rebecca

The Construction of Analogy-Based Research Programs

The Lock-and-Key Analogy in 20th Century Biochemistry

Series:Science Studies

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    eBook (PDF)
    Publication Date:
    2019
    Copyright year:
    2019
    To be published:
    March 2019
    ISBN
    978-3-8394-4442-9
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    Overview

    Aims and Scope

    When the German chemist Emil Fischer presented his key-lock hypothesis in 1899, his analogy to describe the molecular relationship between enzymes and substrates quickly gained vast influence and provided future generations of scientists with a tool to investigate the relation between chemical structure and biological specificity.
    Rebecca Mertens explains the appeal of the lock-and-key analogy by its role in model building and in the construction of long-term, cross-generational research programs. She argues that a crucial feature of these research programs, namely ascertaining the continuity of core ideas and concepts, is provided by a certain way of analogy-based modelling.

    Details

    230 pages
    TRANSCRIPT
    Language:
    English
    Keyword(s):
    Analogy,Research Program,Molecular Biology,Biochemistry,History of Science,Science,Medicine,Philosophy of Science,Sociology of Science,Life Sciences,History
    Readership:
    Professional and scholarly;

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