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Ostash, Bohdan

Regulatory Genes of AdpA Subfamily in Streptomyces: Function and Evolution

Biology of AdpA Regulators in Streptomyces

SCIENDO

    20,00 € / $23.99 / £18.00*

    eBook (PDF)
    Publication Date:
    September 2018
    Copyright year:
    2018
    ISBN
    978-3-11-062777-0
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    Overview

    Aims and Scope

    AdpA is a regulatory protein of the AraC/XylS type which was first identified in 1993 as an activator of streptomycin production by Streptomyces griseus. Today streptomycete genomes are known to invariably harbor gene adpA, which is important for processes as diverse as replication and transcriptional control of genes for morphogenesis, antibiotic biosynthesis, and polymer decomposition to name just a few. Extreme pleiotropicity of adpA gene and its functional location at the nexus of morphological and physiological differentiation in Streptomyces fueled numerous investigations of this fascinating group of regulators, in a broad set of species. This monograph is an attempt to put together all existing information about functions of AdpA proteins in the context of biological processes it orchestrates. Special attention is paid to the description of suggested and experimentally proven cases of AdpA involvement in regulation of antibiotic production. This aspect of AdpA biology might be of great interest for current efforts to discover novel antibiotics, which are desperately needed to counter the threat of multidrug resistant bacterial infections. Possible scenarios of origin and ongoing evolution of adpA orthologous group in Streptomyces conclude this monograph.

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    Details

    67 pages
    SCIENDO
    Language:
    English
    Type of Publication:
    Monograph
    Keyword(s):
    Streptomyces, antibiotics, AdpA, AraC/XylS type regulators, transcriptional factors, morphogenesis

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