High pressure chemistry is a widely used methodology in organic synthesis which helps to increase the rate and to improve the efficiency of chemical processes. The current publication outlines the impact of pressure on many types of chemical reactions important from synthetic point of view and gives practical considerations how to plan and perform synthetic experiments under high pressure in the lab.
Gives an overview of recent developments in the field. Explains the possibilities to reduce reaction times, increase yields and improve regio- and stereoselectivity applying high pressure. Contains numerous examples of natural product syntheses.
Davor Margetic, Ruder Boskovic Institute, Zagreb, Croatia.