Protein interaction partners of NDE1 and NDEL1.
Proteins in the left circle interact with NDE1, those in the right circle with NDEL1. Proteins in the intersecting region are known to interact with both proteins. In the majority of instances where a protein is listed as interacting with only one of NDE1/NDEL1, the reciprocal experiment to test for interaction with the other of NDEL1/NDE1 has not been published to the best of our knowledge. Proteins listed in italics are known to exist in a complex with NDE1/NDEL1 but do not, or have not yet been shown to, directly bind to it. Data are taken from the following papers (1–5, 27–29, 31–33, 48, 50, 53, 57, 58, 63, 65, 66, 68, 72, 74–76, 78, 80, 88, 90, 96–98, 100, 101, 113–121). In some cases the essential binding regions for these interaction partners have been delineated on NDE1 or NDEL1; these are shown schematically in Figure 4.