Figure 1:

Molecular pathways mediating the effects of microRNAs (miRs) on vascular calcification.

RUNX2, Runt-related transcription factor 2; Mef2c, myocyte enhancer factor 2c; NFIA, nuclear factor IA; Pit-1, type III sodium-dependent Pi cotransporter-1; Enpp1, ectonucleotide phosphodiesterase; NCX1, sodium/calcium exchange member 1; PMCA1, plasma membrane calcium pump isoform 1; NCKX4, sodium/potassium/calcium exchange member 4; PDGF, platelet-derived growth factor; KLF, Krüppel-like factor.

Stimulation;
Inhibition.

© De Gruyter