Figure 1:

WIN55,212-2 prevents the effects of shock and situational reminders (SR) on extinction.

(A) On Extinction 1, the shock groups (shock-no SR, shock-SR) demonstrated increased latency compared with the no-shock groups. On Extinctions 2–4, the shock-SR group demonstrated increased latency compared with all groups (*p<0.05; **p<0.01; ***p<0.001). This suggests that exposure to SRs exacerbated the effects of the shock on extinction kinetics. (B) When WIN55,212-2 (WIN) was injected 2 h after the shock, the shock-SR vehicle (Veh) group showed increased latency compared with the shock-no SR WIN group on Extinction 2. On Extinctions 3 and 4, the shock-SR Veh group showed increased latency compared with all groups (*p<0.05; **p<0.01; ***p<0.001). Hence, WIN55,212-2 prevented the shock/SR-induced impairment in extinction kinetics (data published by Korem and Akirav [66] in Neuropsychopharmacology).

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