Figure 1:

Differentiation of “homogeneous” ANA patterns on HEp-2 cells (left: overview; right: metaphase cells).

(A) Dense fine speckled pattern of the interphase nuclei (1) as well as of the metaphase chromatin (2) of a DFS70 antibody; (B) classic homogeneous ANA pattern of a dsDNA antibody with homogeneous-peripheral staining of the interphase nuclei (1) as well as of the chromatin in all mitotic phases (2,3); (C) “quasi-homogeneous” ANA pattern with homogeneous fine-granular staining of the interphase nuclei as well as of the metaphase chromatin of an autoantibody of unknown specificity.

© De Gruyter