The basic concepts, technical implementation, and application scenarios of computer simulation, virtualization, and cloud computing are intertwined and each has its characteristics. In this article, the basic concepts, necessity, feasibility, and core difficulties of computer simulation, virtualization, and cloud computing are analyzed. Also, the application prospects of the three technologies are expounded, the technical differences are analyzed, and the application of some key technologies in the data center is introduced. The generalization of computer simulation technology, the specialization of virtualization technology, and the systematization of cloud computing technology are expounded, which represent the mainstream direction of technology development in the field of information and communication at this stage. The application examples of the three in the aerospace telemetry, tracking, and command field are taken to illustrate that information technology essentially serves the business logic of their respective fields, which also well reflects the basic characteristics of demand-oriented, safety-oriented, innovation, and long-term development. It has guiding significance for the technical orientation, technical selection, and engineering implementation of information system architecture design.